Context
Nuclear medicine has evolved considerably over recent years with the emergence of radiotheranostics, a modality which combines targeted diagnosis and therapy using radioisotopes. It offers an important and promising alternative in the treatment of many cancers. Radiotheranostics is based on the use of radioactive isotopes which, when they decay, emit radiation that enables cancer cells to be precisely located and/or destroyed. Among these radioisotopes, one of the most promising therapeutic is the alpha-emitting Actinium-225.
One of the main challenges to make this therapeutic isotope accessible for the greatest number of patients is ensuring the availability of high-quality Actinium-225 in large quantities. It is often referred within the community as “the rarest drug on Earth”. By joining their unique expertise and resources, SCK CEN and IBA have launched the company PanTera, which aims at enabling the production of Actinium-225.
In this context, PanTera is looking for a talented and experienced Senior Radiochemist to support the manufacturing of GMP-grade Actinium-225. The successful candidate will be primarily responsible for developing and industrializing the radiochemistry process of PanTera. The role is critical to our operations and requires great technical and operational knowledge.
Responsibilities
* Design and optimize radiochemical separation and purification processes
* Collaborate with a cross-functional team to support the development of these radiochemical processes
* Perform radiochemical and chemical analysis using various analytical techniques such as alpha and gamma spectrometry or ICP-MS
* Support the translation of PanTera’s innovative radiochemistry process to a compliant GMP production line (developing procedures, selecting consumables,…).
* Contribute to the requirement definition and selection of the necessary equipment and tools to support the radiochemical process
* Prepare the future operations of the lab, ensuring timely and efficient production schedules, in accordance with customer requests
* Train and mentor future operation staff
* Work in close coordination with the Regulatory department to ensure all radiochemistry operations comply with applicable regulations
* Work in close coordination with the Quality department to ensure all radiochemistry operations comply with quality standards
* Implement and monitor Safety protocols, ensuring that all radiochemistry activities and operations adhere to safety standards and regulations
* Drive innovation by keeping track of latest development in radiochemistry field and integrate best practices into PanTera’s operations
Profile
* PhD or Master’s degree in Radiochemistry, Nuclear Chemistry or related field
* A minimum of 10 years of experience in radiochemistry. Knowledge of Actinium-225 or alpha-emitters is a plus. Proven experience in translating lab-scale processes to GMP production line.
* In-depth understanding of radiochemistry processes, equipment and tools. Great knowledge of safety and GMP regulations and requirements.
* Excellent verbal and written communication skills, with ability to collaborate effectively with multiple stakeholders.
* Strong analytical and problem-solving abilities to address complex technical challenges.
* Fluent in English
Our offer
This role presents a unique opportunity to be part of a dynamic start-up, contributing to the production of essential products in the field of nuclear medicine. Our company is dedicated to supplying a highly demanded drug in this rapidly expanding market. Leveraging the exceptional know-how and advanced technology of our founders, we are uniquely positioned for success and poised to make a significant impact in the healthcare sector. As part of our team, you'll play a crucial role in this exciting and impactful journey.
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