Social network you want to login/join with:
Scientist, Fermentation/Upstream - 6 months fixed term contract, Rixensart
Client:
1849 GlaxoSmithKline Biologicals S.A.
Location:
Rixensart
Job Category:
Other
EU work permit required:
Yes
Job Reference:
4c8e43f9d911
Job Views:
3
Posted:
17.03.2025
Expiry Date:
01.05.2025
Job Description:
Job Purpose :
As a Scientist specialized in the upstream/fermentation field, you will join a team of experts focusing on antigen process development for new vaccine candidates from Phase I up to commercial launch. You will also be involved in Life Cycle activities for process improvements in the commercial vaccine portfolio.
The successful candidate will report to the Head of Development Unit 3 within the Microbila Drug Substance department in Belgium, which is part of the Global Drug Substance organization in Technical R&D (TRD).
Your Responsibilities:
1. You will be expected to lead autonomously the development of bacterial or yeast-based fermentation of antigens (proteins, polysaccharides, toxins), driving implementation of latest industry trends and state-of-the-art technologies into current manufacturing processes, identifying and promoting opportunities for improvements aiming for scalable, high efficiency, robust, and cost-effective manufacturing processes with reduced footprint.
2. You will be expected to have strong project management skills and perform timeline and resource planning estimations, design development strategies, plan experimental protocols, lead horizontally a team of technicians and operators to execute them, having a strong presence in the lab to ensure best practices, compliance with documentation practices and EHS standards.
3. You will be expected to follow the Quality by Design approach to process development, leading multi-disciplinary Technical Risk Assessments and ensuring to meet all documentation deliverables required at each of the project stage gates.
4. You will be expected to support the Development Unit Head in bringing the team (both in your own development unit as well as in the others across the department) to the next level in technical knowledge and best practices, proactively promoting initiatives.
5. You will ensure a strong interface and knowledge sharing with Manufacturing Science and Technology, manufacturing strategy, site management, Process Science, and engineering departments for building related activities such as revamping, scaling-up or tech transfer to new facilities.
6. You will work very closely with the Scale-up team from the development stages to ensure smooth transition throughout the scales required at the different project phases.
7. You will closely collaborate with the In-Process Analytical organization (IPA) to develop IPA strategy and implement IPA testing as fit for upstream processes.
8. You will build strong relationships and a collaborative network with the DS organizations in Italy and the US aimed at increasing sharing and learning, better decision making, stimulating people development and pushing top science & technology throughout the network.
9. You will be expected to write and review project reports including process history files, process development reports, etc.
Why You?
Basic qualifications:
1. Master in bio-engineering, biochemistry, biotechnology, chemistry or equivalent.
2. You already have a first experience in Upstream Drug Substance Development and/or Manufacturing in the biopharma/biotech industry.
3. You are motivated by process development from flask to pilot scale fermentor. You can act as a leader both in the lab and management of a small team of technicians. You have a deep interest in technical aspects of the job and you are willing to participate actively on the shop floor.
4. You are knowledgeable in process development of recombinant proteins and viral vaccines based on different types of hosts.
5. You have a basic understanding of statistical approaches and models of development as well as Quality by Design.
6. Critical thinking and problem-solving skills.
7. Ability to work in a dynamic multidisciplinary environment.
8. Ability to embrace changes positively and adapt.
9. Demonstrated ability to be proactive, take initiative, and lead autonomously.
10. Imprinted with a desire for excellence.
11. Optimistic and open-minded.
12. Fluent in spoken and written English scientifically/technically as well as conversational are a MUST.
13. Being able to communicate in French or willing to learn.
Preferred qualifications:
1. Ideally a first experience in fermentation or cell culture in research or manufacturing, particularly in bacteria and yeast expression systems.
2. A good understanding of clinical and commercial manufacturing processes and manufacturing constraints.
3. A good understanding and knowledge of process industrialization methods.
4. Understanding in continuous manufacturing, Systems Biology (-omics), big data, multivariate analysis, predictive analytics and modelling approaches.
#Li-GSK
If you have a disability and require assistance during the course of the selection process, you will have the opportunity to let us know what specific assistance you require in order to make suitable arrangements.
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organization where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/immunology, and oncology).
Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged, and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.
Important notice to Employment businesses/ Agencies
GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK.
#J-18808-Ljbffr